Volume 33, No 7, Jul 2023

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The lotus beneath Nezha, a fairy tale character, represents an ER anion channel CLCC1. Chloride through CLCC1 compensates both potential and osmolality changes during ER Ca2+ release together with K+ (2Ca2++Cl–=3K+). CLCC1 dysfunction leads to imbalance of ER ion homeostasis (2Ca2+=4K+), ER swelling, and neurodegeneration, which is linked with ALS represented by Nezha’s frozen leg and spear. See page 497–515 by Liang Guo et al. for details.

Advanced Online Publication: 28 Jun 2023

RESEARCH HIGHLIGHTS

Lysine metabolism at the nexus of crotonylation and tumor immunity

How CHKing ROS signaling preserves genomic integrity

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Current Issue: Vol.33 (Jul 2023)

RESEARCH HIGHLIGHTS

Identity revealed for a long-sought ER anion channel
Transgenerational inheritance of engineered cytosine methylation in mice
Precision medicine for metastatic TNBC: the FUTURE is now
A sticky solution to protein-selective sugar installation
RNA editing: new roles in feedback and feedforward control

ORIGINAL ARTICLES

Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
Structure and transport mechanism of the human calcium pump SPCA1
Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis

LETTERS TO THE EDITOR

Bacterial coinfections contribute to severe COVID-19 in winter
Structure of the SNAPc-bound RNA polymerase III preinitiation complex

CORRIGENDA

Author Correction: Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing