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LETN and NPM1 tango in human nucleoli
Guang Xu1 , Man Wu1 , Ling-Ling Chen1,2,3,*1State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
In a recent paper published in Cell Research, Wang et al. identify a nucleolar-localized long noncoding RNA (lncRNA), LETN (lncRNA essential for tumor cell proliferation via NPM1) and depict a mutually dependent NPM1–LETN interaction that is essential for maintaining nucleolar function and sustaining cancer cell proliferation.