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Sensing unsaturated fatty acids: insights from GPR120 signaling
Shicheng Zhang , Bryan L. RothDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
GPR120 is a receptor that plays a crucial role in mediating the beneficial effects of free fatty acids (FAs), particularly ω-3 FAs, on metabolic and inflammatory pathways, making it an important therapeutic target for metabolic diseases. Recently, Mao et al. report the cryo-EM structures of GPR120 in complex with an ω-3 FA as well as other three endogenous FAs and a synthetic agonist, along with pharmacological investigations and molecular dynamics simulations, thereby providing comprehensive insights into the molecular recognition and biased signaling of GPR120 via various agonists.