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CAR T cell design: approaching the elusive AND-gate
Zeguo Zhao , Michel SadelainCenter for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Logic gating is a strategy for chimeric antigen receptor (CAR) T cell therapy to target tumor cells that lack tumor-specific antigens and prevent on-target/off-tumor toxicity. In a recent Nature article, Tousley et al. present an elegant CAR T cell AND-gate design to enhance CAR T cell safety without compromising efficacy.