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How “rock-and-roll” solved the cullin supply chain problem
Sheena Faye Garcia1 , Michele Pagano1,2,*1Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA
In a recent study published in Cell, Baek et al. used cryo-electron microscopy to capture transitional conformations of Cand1, a regulator of SCF ubiquitin ligases, depicting its utilization of a “rock-and-roll” mechanism to both displace substrate receptors from the catalytic core and allow new substrate receptors to bind in their place.