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Accelerated transcriptional elongation during aging impairs longevity
Alexander Tyshkovskiy1 , Sirui Zhang1 , Vadim N. Gladyshev1,2,*1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Increased transcriptional errors in aged organisms have been demonstrated for multiple species; however, mechanistic details remained elusive. In a recent issue of Nature, Debès et al. reveal a novel form of aging-associated molecular damage, demonstrating that Pol II transcriptional elongation rate increases with age, presumably due to reduced nucleosomal density, whereas targeted reduction of Pol II speed can partially ameliorate this deleterious phenotype and extend lifespan in animals, such as roundworms and fruit flies.