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GPCRs and β-arrestins — an on-off relationship
Alex R. B. Thomsen1,2,*1Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA
Traditionally, G protein-coupled receptor (GPCR)-mediated G protein signaling has been thought to be terminated by receptor phosphorylation followed by recruitment of β-arrestins, which uncouples G protein from the receptor. However, new detailed insights published in Cell by Grimes et al. suggest that the initial agonist-stimulated β-arrestin accumulation at the cell membrane and GPCR–β-arrestin association are mechanistically distinct and much more dynamic than previously appreciated.