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6mA-METL-9 axis regulates innate immunity in C. elegans
Tong Wu1,2 , Chuan He1,2,3,*1Department of Chemistry, The University of Chicago, Chicago, IL, USA
While prevalent in prokaryotes, physiological function and potential regulation of DNA 6mA modification in eukaryotes have yet to be fully explored. In a new study published in Cell Research, Ma et al. identified METL-9 as a DNA 6mA methyltransferase in Caenorhabditis elegans, and demonstrated that METL-9 could regulate innate immunity through 6mA-dependent and -independent pathways, suggesting new mechanisms for combating pathogen infection in eukaryotes.