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How CHKing ROS signaling preserves genomic integrity

Annapoorna Venkatachalam¹ , Scott H. Kaufmann^1,2,*

¹Division of Oncology Research, Mayo Clinic, Rochester, MN, USA
²Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA
* Correspondence: Scott H. Kaufmann(Kaufmann.Scott@Mayo.edu)

In a recent study published in Cell, Zhang et al. broadly identify proteins modified during oxidative stress induced by H2O2 or chemotherapy drugs and establish the DNA damage protein CHK1 as a key regulator of mitochondrial ROS.

https://doi.org/10.1038/s41422-023-00840-0

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