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How CHKing ROS signaling preserves genomic integrity
Annapoorna Venkatachalam1 , Scott H. Kaufmann1,2,*1Division of Oncology Research, Mayo Clinic, Rochester, MN, USA
In a recent study published in Cell, Zhang et al. broadly identify proteins modified during oxidative stress induced by H2O2 or chemotherapy drugs and establish the DNA damage protein CHK1 as a key regulator of mitochondrial ROS.