Volume 33, No 7, Jul 2023
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 7, July 2023: 489-490
Transgenerational inheritance of engineered cytosine methylation in mice
Maximilian M. L. Knott* , Oded Rechavi*Department of Neurobiology, George S. Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
The occurrence of transgenerational epigenetic inheritance has overwhelming evidence in plants and invertebrates; however, the substantial erasure of DNA and histone modifications during early embryogenesis has been considered an insurmountable barrier to the transmission of epigenetic information in mammals. In a recent issue of Cell, Takahashi et al. demonstrate that engineered DNA methylation states of promoter-associated CpG islands can be inherited for multiple generations in mice.