Volume 33, No 7, Jul 2023

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 33 Issue 7, July 2023: 489-490

RESEARCH HIGHLIGHTS

Transgenerational inheritance of engineered cytosine methylation in mice

Maximilian M. L. Knott^* , Oded Rechavi^*

Department of Neurobiology, George S. Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
Correspondence: Maximilian M. L. Knott(knott.max@gmail.com)Oded Rechavi(odedrechavi@gmail.com)

The occurrence of transgenerational epigenetic inheritance has overwhelming evidence in plants and invertebrates; however, the substantial erasure of DNA and histone modifications during early embryogenesis has been considered an insurmountable barrier to the transmission of epigenetic information in mammals. In a recent issue of Cell, Takahashi et al. demonstrate that engineered DNA methylation states of promoter-associated CpG islands can be inherited for multiple generations in mice.

https://doi.org/10.1038/s41422-023-00799-y

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