Volume 33, No 7, Jul 2023
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 33 Issue 7, July 2023: 487-488
Identity revealed for a long-sought ER anion channel
Laura Bianchi*Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, USA
Ca2+ release from the endoplasmic reticulum (ER) requires flux of counterions. In a recent paper published in Cell Research, Guo and colleagues, using a powerful combinatorial approach, show that CLCC1 is the long-sought mediator of Cl– efflux from the ER that counteracts Ca2+ release and that its loss causes ER stress and contributes to ALS pathology.