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      Volume 33, No 7, Jul 2023

      ISSN: 1001-0602 
      EISSN: 1748-7838  
      2020 impact factor 25.617*  
      (Clarivate Analytics, 2021)

      About the cover

      The lotus beneath Nezha, a fairy tale character, represents an ER anion channel CLCC1. Chloride through CLCC1 compensates both potential and osmolality changes during ER Ca2+ release together with K+ (2Ca2++Cl–=3K+). CLCC1 dysfunction leads to imbalance of ER ion homeostasis (2Ca2+=4K+), ER swelling, and neurodegeneration, which is linked with ALS represented by Nezha’s frozen leg and spear. See page 497–515 by Liang Guo et al. for details.

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